L-Threonine

L-Threonine

Origin
: China
HS Code
: 2922.50.90
Basic Info
Physical State
: Solid
Appearance / Color
: White crystalline powder
Odor
: Characteristic
Moisture Content (%)
: <0.5%
pH
: 5.0-7.0
Synonyms & Trade Names
: L-Threonine; (2S,3R)-2-amino-3-hydroxybutanoic acid
Total Plate Count (TPC)
: <50,000 CFU/g
Yeast & Mould
: <500 CFU/g
E. Coli
: Negative/25g
Salmonella
: Negative/25g
Shelf Life
: 24 months
Packaging Size
: 25 kg
Packaging Type
: PP woven bag
Storage Conditions
: Cool, dry place
Halal Certification
: Available
Kosher Certification
: Available
ISO / HACCP
: Yes
Food Grade / Regulatory Status
: Feed grade
Crude Protein (%, min)
: ~68%
Total Volatile Basic Nitrogen (TVN/TVBN, mg/100g)
: Not applicable
Active Ingredient Assay (%)
: 98.5% min
Antioxidant Treatment
: None
Species of Origin Declaration
: N/A (fermentation)
EU Feed Additive Authorization No.
: E921
Aflatoxin B1
: Not applicable
Heavy Metals — Feed (As, Pb, Hg, Cd)
: Compliant
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Technical Document

Brief Overview
Threonine is an amino acid with the chemical formula of C4H9NO3 and is used in the biosynthesis of proteins. It contains an α-amino group, a carboxyl group, and a side chain containing a hydroxyl group, making it a polar, uncharged amino acid. Threonine is synthesized from aspartate in bacteria such as E. coli.
Manufacturing Process
Threonine is an important amino acid which is used in animal feeds and medicines. One process which is known for its production is a fermentation method. In this technique a mutant of the genus Brevibacterium having resistance to bacterial α-amino-β-hydroxyvaleric acid (hereinafter referred to as AHV) which is a threonine analog is cultured. This process employs as an AHV-resistant mutant, a strain having homoserine dehydrogenase (hereinafter referred to as HD) in which feedback inhibition due to threonine has been removed. The yield of threonin produced by this process is low, and therefore, it is not an economical method for the production of threonine which is added to animal feeds. Accordingly, in order to enhance the yield of threonine, a mutant which is frequently used is one which is a lysine-producing strain. However, in this case, lysine is frequently produced as a by-product, which adversely affects the yield of threonine. Further, the separation of lysine from the medium is a complicating factor. A need therefore continues to exist for a method of producing threonine in improved yields by a fermentation technique.